The quantitation of the competing energetics of the stereoelectronic and steric effects of the 3 '-OH and the aglycone in the alpha- versus beta-D- & -L-2 '-deoxyribonucleosides by H-1-NMR

• By comparative NMR study of 2',3'-dideoxynucleosides (see ref 1) with alpha-D- or L-2'-deoxynucleosides, we have been able to quantify for the first time the competing medium-dependent influences of the 3'-OH promoted gauche and the aglycone-configuration

Keyword

PROTON COUPLING-CONSTANTS; HIGH-FIELD H-1-NMR; CONFORMATIONAL-ANALYSIS; PSEUDOROTATIONAL EQUILIBRIUM; PENTOFURANOSE MOIETY; SUBSTITUENT ELECTRONEGATIVITIES; BIOLOGICAL-ACTIVITY; SUGAR CONFORMATION; C-NUCLEOSIDES; FURANOSE RING

Publication and Content Type

vet (subject category)

art (subject category)